Use of data processing for rapid detection of the prostate-specific antigen biomarker using immunomagnetic sandwich-type sensors

• Camila A. Proença,
• Tayane A. Freitas,
• Thaísa A. Baldo,
• Elsa M. Materón,
• Flávio M. Shimizu,
• Gabriella R. Ferreira,
• Frederico L. F. Soares,
• Ronaldo C. Faria and
• Osvaldo N. Oliveira Jr.

Beilstein J. Nanotechnol. 2019, 10, 2171–2181, doi:10.3762/bjnano.10.210

• treatment for determining biomarkers in real samples. In this paper, we report an immunomagnetic nanoparticle-based microfluidic sensor (INμ-SPCE) for the amperometric detection of the prostate-specific antigen (PSA) biomarker, the data of which were treated with information visualization methods. The INμ

• ; nanoarchitectonics; information visualization; sandwich-type immunosensors; screen-printed electrodes; Introduction The prostate-specific antigen (PSA) used in clinical diagnosis is present in normal prostatic secretions, but its concentration is often elevated in prostate cancer patients. In spite of its lack of

• sparked interest in computational tools [31]. For instance, information visualization techniques have been used to enhance the distinguishing ability of biosensors [32][33][34]. Discrimination of blood serum samples from patients with distinct probability to develop pancreatic cancer was made possible